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Session Details

Cytiva Presentation: Ex Vivo Engineering of Primary Cells Using RNA-Lipid Nanoparticles and Scale-Up Manufacturing for Cell and Gene Therapies
Friday, May 31, 2024 12:30 PM - 12:45 PM  
Exhibit Hall - Theatre B
Global Showcase Presentation

Presenter:

  • Dr. Samuel Clarke, Director of R&D, Cytiva, Canada

Delivering nucleic acids using lipid nanoparticles (LNP) to target cells has tremendous potential to enable new cell and gene therapies. In this presentation, we will discuss a genomic medicine toolkit composed of technologies that enable the development of RNA-LNP medicines. This includes off-the-shelf reagents for producing RNA-LNPs optimized for specific cell types, and the NxGen manufacturing platform designed for rapid development and scalable manufacture of RNA-LNPs from lab scale (mL) to GMP manufacturing (Liters).

We will showcase data in the areas of ex vivo CAR T cell and hematopoietic stem cell therapies where LNPs enable RNA delivery for transient expression of therapeutic genes and gene editing nucleases. In addition, we will share data demonstrating scale-up and manufacture of RNA-LNPs using a GMP-compliant process.


SPONSORED BY:
Samuel Clarke
Director of R&D
Cytiva
Presenter