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Session Details

SCIENCE & INNOVATION CONCURRENT Promise and obstacles of cell-derived nanovesicular therapeutics
Thursday, June 1, 2023 08:00 AM  
Amphitheatre Bleu
SCIENCE & INNOVATION
Concurrent
Chair
Eva Rohde, MD, Paracelsus Medical University Salzburg

Speakers
Pieter Vader, PhD, UMC Utrecht University
Ewa Zuba-Surma, PhD, Jagiellonian University in Krakow
Mario Gimona, PhD, Paracelsus Medical University Salzburg
 
Nanovesicular therapeutics (NVTs) are expected to have entirely novel properties in targeted drug delivery, providing a promising therapeutic platform for diseases with previously untreatable molecular targets or high unmet clinical need.
Various concepts and technologies have been developed, such as the use of externally loaded nanovesicles or naturally secreted extracellular vesicles from unmodified or genetically modified cells from different starting materials.
 
Artificially formed nanovesicular structures generated by serial extrusion techniques from living cells or hybrid constructs derived from a combination of synthetic and biological materials are increasingly being investigated. Few clinical trials have been conducted to date, and proof of efficacy in pivotal studies is still pending, yet expectations are high. This session is devoted to the technological considerations of NVT and the associated therapeutic prospects.

Eva Rohde MD
Director GMP Unit and Head of the Department of Transfusion Medicine
Paracelsus Medical University Salzburg
Chair


Mario Gimona
Head of Manufacturing
Paracelsus Medical University Salzburg
Speaker


Pieter Vader PhD
Associate Professor
University Medical Center Utrecht
Speaker


Ewa K. Zuba-Surma PhD, DSc
Full Professor, Head of Research group. President of Polish Society for Extracellular Vesicles
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University
Speaker