PRECISION NANOSYSTEMS GLOBAL SHOWCASE PRESENTATION RNA Lipid Nanoparticles Enable Non-Viral Genetic Engineering of T cells and CD34+ HSPCs for Cell and Gene Therapies
Thursday, June 1, 2023 01:15 PM - 01:30 PM
Global Showcase Theater
Global Showcase Presentation
RNA Lipid Nanoparticles Enable Non-Viral Genetic Engineering of T cells and CD34+ HSPCs for Cell and Gene Therapies
Presenter
Dr. Angela Zhang, Senior Product Manager, Precision NanoSystems, Canada
Delivering nucleic acids using lipid nanoparticles (LNP) to target cells has tremendous potential to enable new gene and cell therapies. However, limited access to novel LNP solutions beyond vaccines can be a barrier to adoption. Herein, we describe a library of ionizable lipids that can be used as functional excipients for nucleic acid delivery for different routes of administrations. To exemplify the benefits of LNPs in the production of cell-based therapies, we demonstrate a robust method for the multi-step engineering of gene-edited CAR T cells and CD34+ hematopoietic stem and progenitor cells (HSPCs) using off-the-shelf LNP reagents with a scalable path to the clinic.
Presenter
Dr. Angela Zhang, Senior Product Manager, Precision NanoSystems, Canada
Delivering nucleic acids using lipid nanoparticles (LNP) to target cells has tremendous potential to enable new gene and cell therapies. However, limited access to novel LNP solutions beyond vaccines can be a barrier to adoption. Herein, we describe a library of ionizable lipids that can be used as functional excipients for nucleic acid delivery for different routes of administrations. To exemplify the benefits of LNPs in the production of cell-based therapies, we demonstrate a robust method for the multi-step engineering of gene-edited CAR T cells and CD34+ hematopoietic stem and progenitor cells (HSPCs) using off-the-shelf LNP reagents with a scalable path to the clinic.
